Sandra Bullock

Scarlet Overkill (voice)

Jon Hamm

Herb Overkill (voice)

Michael Keaton

Walter Nelson (voice)

Allison Janney

Madge Nelson (voice)

Steve Coogan

Professor Flux / Tower Guard (voice)

Jennifer Saunders

Reine Elizabeth II (voice)

Geoffrey Rush

Narrator (voice)

Steve Carell

Gru (voice)

Pierre Coffin

Kevin / Stuart / Bob / The Minions (voice)

Katy Mixon

Tina (voice)